Rapid Analysis of Chemical Drugs Using the Near-infrared Spectroscopic Technology
Chapter 1 NIR Spectrometer / 7 Classification and Characteristics of NIR Spectrometer / 7 Key Performance Indicators of NIR Spectroscopic Instrument / 11 Acquisition of NIR Spectrum / 16 NIR Spectrometer in Mobile lab / 17
Chapter 2 Introduction Near-infrared Analysis Methods / 20 Spectral Data Preprocessing Methods / 21 Qualitative Analysis Method / 25 Cluster Analysis / 31 Quantitative Analysis / 35 Conformity Test Analysis / 45 Correlation Coefficient Analysis / 49 Methods of Model Transfer / 52
Chapter 3 Application of NIR Methods in Drug Analysis / 58 Analysis of Antibiotics Using NIR Methods / 59 CASE STUDY 1 Establishment of Qualitative NIR Models for the Analysis of Cephalosporin Injection Powder Products / 61 CASE STUDY 2 Rapid Determination of Cefuroxime Sodium Content Using NIR Analysis / 66 CASE STUDY 3 Construction of a Universal NIR Model for Quantitative Analysis of Cefradine Capsules / 73 CASE STUDY 4 Development of a Universal NIR Model for Quantitative Analysis of Phenoxymethylpenicillin Potassium Tablets / 79 CASE STUDY 5 Universal NIR Models for the Quantitative Analysis of Ceftriaxone and Water Contents in Ceftriaxone Sodium Injection Products / 85 Analysis of Chemical Drugs Using NIR Methods / 96 CASE STUDY 6 Construction of a Quantitative Model for Simvastatin Tablets / 98 CASE STUDY 7 NIR Models for Quantitative Analysis of Aminosalicylate and Water Contents in Sodium Aminosalicylate Injections / 102 CASE STUDY 8 Rapid Analysis of Potassium Dehydroandrographolide Succinate Injection Using NIRDRS / 108 CASE STUDY 9 NIR Identification and Analysis of Compound Paracetamol and Amantadine Hydrochloride Tablets / 115 Application of NIR Spectroscopy in the Analysis of Traditional Chinese Medicines (TCM) / 120 CASE STUDY 10 Establishment of a Qualitative NIR Model for Cortex Magnoliae officinalis / 122 CASE STUDY 11 Analysis of Water Content in Liuwei Dihuang Pills Using NIR Spectroscopy / 129 CASE STUDY 12 Qualitative Analysis of Different Brands of Jianwei Xiaoshi Tablets Using NIR Spectroscopy / 131 CASE STUDY 13 Identification of Decoction Pieces of Common Yam Rhizome by NIR Method / 133 NIR Analysis of Illegal Additives in Medicinal Products / 143 CASE STUDY 14 Illegal Addition of Sildenafil Citrate into Chinese Patent Medicine / 144 CASE STUDY 15 Norfloxacin Addition in Lopermide Hydrochloride Capsules / 146 CASE STUDY 16 NIR Correlation Analysis of Illegal Added Phenformin Hydrochloride in Chinese Patent Medicines / 147 NIR Analysis of Liquid Formulations / 152 CASE STUDY 17 Construction NIR Quantitative Model for Glucose Injection / 154 Applications of NIR Methods on Mobile Laboratory Vehicles / 161 CASE STUDY 18 The Establishment and Application of Blank Models Used for Spectra Comparison / 164 CASE STUDY 19 Establishment and Application of the Characteristic Spectral Range Screening Method / 171
Chapter 4 Prospect of NIR Analysis Methods / 184 Development Prospect of NIR Analytical Instruments / 185 Prospect of the Application of NIR Analysis Method / 186 Prospect of NIR Analysis Methods being Listed in the National Drug Standards of Different Countries / 190 References / 192
Rapid HPLC Forensic Analysis of Chemical Medicines
Chapter 5 Basic Principles and Methods for Rapid HPLC Analysis / 202 Identification / 202 Content Determination / 202 Establishment and Validation of the Rapid HPLC Forensic Method / 203
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