Cell Biology is the most taught basic science course in medical school as it is one of the most rapidly developing subjects in science. Cell biology overlaps with molecular biology， histology， pathology， cancer biology， neuroscience， and many other major related disciplines. Having an up-to-date Cell Biology textbook that covers many functional aspects is essential for medical students to “cross the bridge” between basic sciences and clinical courses. This textbook was edited and modified from Medical Cell Biology， Steven R. Goodman ed.， Elsevier， 2008. The first several chapters serve as comprehensive introductions into organelle structure， functions and gene expression. The second half of this book details many topics in medical science， including cell signaling pathways， cell cycle， programmed cell death， and cancer. New technologies such as atomic force microscopy， proteomics， and gene therapy are also covered.
作者簡介
暫缺《醫(yī)學(xué)細胞生物學(xué)（英文原版改編版）》作者簡介
圖書目錄
Chapter 1 Tools of the Cell Biologist............................1 MICROSCOPY: ONE OF THE EARLIEST TOOLS OF THE CELL BIOLOGIST...................................... 1 MORE TOOLS OF CELL BIOLOGY......................... 11 SUMMARY...................................................................16 SUGGESTED READINGS........................................... 16 Chapter 2 Cell Membranes........................................... 17 THE MOLECULAR STRUCTURE OF CELL MEMBRANE............................................................ 19 MEMBRANE TRANSPORT OF SMALL MOLECULES........................................................... 27 SUMMARY................................................................... 31 SUGGESTED READINGS........................................... 32 Chapter 3 Cytoskeleton.................................................. 33 MICROFILAMENTS.................................................... 33 INTERMEDIATE FILAMENTS................................. 40 MICROTUBULES......................................................... 43 SUMMARY................................................................... 48 SUGGESTED READINGS........................................... 48 Chapter 4 Organelle Structure and Function......... 49 THE NUCLEUS............................................................ 50 ENDOPLASMIC RETICULUM................................. 51 THE GOLGI COMPLEX.............................................. 66 ENDOCYTOSIS, ENDOSOMES, AND LYSOSOMES............................................................ 73 MITOCHONDRIA....................................................... 77 PEROXISOMES............................................................ 87 SUMMARY................................................................... 88 SUGGESTED READINGS........................................... 89 Chapter 5 Cell Nucleus and Gene Expression......... 90 CELL NUCLEUS.......................................................... 90 DNA REPLICATION AND REPAIR ARE CRITICAL NUCLEAR FUNCTIONS................... 98 GENE EXPRESSION.................................................. 104 SUMMARY................................................................. 116 SUGGESTED READINGS......................................... 116 Chapter 6 Cell Adhesion and the Extracellular Matrix........................................................... 117 CELL ADHESION...................................................... 117 INTERCELLULAR JUNCTIONS............................. 119 CELL ADHESION HAS MANY IMPORTANT ROLES IN TISSUE FUNCTION.......................... 128 CELL ADHESION RECEPTORS TRANSMIT SIGNALS THAT REGULATE CELL BEHAVIOR.........................................................................133 EXTRACELLULAR MATRIX................................... 134 SUMMARY.................................................................140 SUGGESTED READINGS......................................... 141 Chapter 7 Intercellular Signaling............................. 142 GENERAL MODES OF INTERCELLULAR SIGNALING........................................................... 142 HORMONES............................................................... 144 XII 醫(yī)學(xué)細胞生物學(xué)Meeddiiccaall Ceellll Biioollooggyy GROWTH FACTORS................................................ 146 GASES: NITRIC OXIDE AND CARBON MONOXIDE........................................................... 148 NEUROTRANSMITTERS......................................... 150 SUMMARY................................................................. 154 SUGGESTED READINGS......................................... 155 Chapter 8 Cell Signaling Events................................ 156 SIGNALING IS OFTEN MEDIATED BY CELLSURFACE RECEPTORS....................................... 156 RECEPTOR TYROSINE KINASES AND RASDEPENDENT SIGNAL TRANSDUCTION...... 157 SIGNALING BY CATALYTIC RECEPTORS/ SERINE-THREONINE KINASES....................... 160 SIGNALING BY NONKINASE RECEPTORS....... 163 SIGNALING BY G-PROTEIN-COUPLED RECEPTORS INVOLVES CLEAVAGE OF GUANOSINE TRIPHOSPHATE TO GUANOSINE DIPHOSPHATE.......................... 166 SIGNALING BY STEROID HORMONE RECEPTORS REQUIRES LIGAND INTERACTION WITHIN THE CYTOPLASM OR NUCLEUS............................. 167 OTHER SIGNALING PATHWAYS SIGNALING BY THE RENINANGIOTENSIN- ALDOSTERONE SYSTEM....169 SIGNALING BY THE JAK/STAT PATHWAY..... 170 CALCIUM/CALMODULIN SIGNAL TRANSDUCTION................................................. 170 SIGNALING BY ION CHANNEL RECEPTORS..........171 SUMMARY................................................................. 172 SUGGESTED READINGS......................................... 172 Chapter 9 The Cell Cycle and Cancer..................... 173 CELL CYCLE: HISTORY.......................................... 173 THE CELL CYCLE IS REGULATED BY CYCLIN AND RELATED PROTEINS............... 174 MITOSIS...................................................................... 176 MEIOSIS ..................................................................... 179 SENSORS RECOGNIZE SITES OF DNA DAMAGE............................................................... 181 CELL-CYCLE ALTERATIONS AND CANCER ..........183 SUMMARY................................................................. 184 SUGGESTED READINGS......................................... 184 Chapter 10 Programmed Cell Death........................ 185 DISTINCT FORMS OF PROGRAMMED CELL DEATH................................................................... 186 NEUROTROPHIN RECEPTORS............................. 189 CASPASES.................................................................. 191 SIGNALING PATHWAYS THAT PROMOTE CELL SURVIVAL.................................................. 197 APOPTOSIS AND HUMAN DISEASE................... 200 SUMMARY................................................................. 201 SUGGESTED READINGS......................................... 201
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