Foreword,vii.
Preface,ix
Contributors,xiii
Abbreviatioffs,xv
GENERALPRINCIPLES.
1HistoricalBackgroundandOverview,1
2SaccharideStructureandNomenclature,17
3EvolutionofGlycanDiversity,31
4Protein-GlycanInteractions,41
5ExploringtheBiologicalRolesofGlycans,57
BIOSYNTHESIS,METABOLISM,ANDFUNCTION
6MonosaccharideMetabolism,69
7N-Glycans,85
8O-Glycans,101
9Glycosphingolipids,115
10GlycophospholipidAnchors,131
11ProteoglycansandGlycosaminoglycans,145
12OtherClassesofGolgi-derivedGlycans,161
13NuclearandCytoplasmicGlycosylation,171
14TheO-GIcNAcModification,183
15SialicAcids,195
16StructuresCommontoDifferentTypesofGlycans,211
17Glycosyltransferases,253
18DegradationandTurnoverofGlycans,267
19Glycosylationin"Model"Organisms,285.
20GlycobiologyofPlantCells,305
21BacterialPolysaccharides,321
PROTEINSTHATRECOGNIZEGLYCANS
22DiscoveryandClassificationofAnimalLectins,333
23P-typeLectins,345
24I-typeLectins,363
25C-typeLectins,379
26Selectins,391
27S-typeLectins(Galectins),417
28MicrobialGlycan-bindingProteins,429
29Glycosaminoglycan-bindingProteins,441
30PlantLectins,455
GLYCANSINGENETICDISORDERSANDDISEASE
31GeneticDisordersofGlycosylationinCulturedCells,469
32NaturallyOccurringGeneticDisordersofGlycosylation,479
33DeterminingGlycanFunctionUsingGeneticallyModifiedMice,499
34GlycosylationChangesinOntogenyandCellActivation,515
35GlycosylationChangesinCancer,537
36GlycobiologyofProtozoalandHelminthicParasites,551
37AcquiredGlycosylationChangesinHumanDisease,565
METHODSANDAPPLICATIONS
38StructuralAnalysisandSequencingofGlycans,581
39ChemicalandEnzymaticSynthesisofGlycans,599
40NaturalandSyntheticInhibitorsofGlycosylation,609
41GlycobiologyinBiotcdmologyandMedicine,625
Glossary:CommonlyUsedTerms,635
Index,641...
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