Contributors Preface Preface to the First Edition UNIT 1 GENERAL PRINCIPLES OF TOXICOLOGY 1 History and Scope of Toxicology 2 Principles of Toxicology 3 Mechanisms of Toxicity 4 Risk Assessment UNIT 2 DISPOSITION OF TOXICANTS 5 Absorption,Distribution,and Excretion fo Toxicants 6 Biotransformation of Xenobiotics 7 Toxicokinetics UNIT 3 NOT-ORGAN-DIRECTED TOXICITY 8 Chemical Carcinogenesis …… UNIT 4 TARGET ORGAN TOXICITY UNIT 5 TOXIC AGENTS UNIT 6 ENVIRONMENTAL TOXICOLOGY UNIT 7 APPPLICATIONS OF TOXICOLOGY Appendix:Recommended Limits for Occupational Exposure to Chemicals Index